Comparison of hematological parameters of JAK2 positive and JAK2 negative patients of polycythemia vera: A mini-review

Abstract

Polycythemia vera (PV) is a malignant disorder with a different frequency based upon age and population. The present review aimed to determine the frequency of Janus Kinase-2 (JAK2) positive and JAK2 negative patients with PV and compare the hematological parameters. Operating polymerase chain reaction (PCR), studies found that mutations in the patients of JAK-2 V617F gene with low serum erythropoietin (EPO) and bone marrow depicted hypercellularity with increased red cell mass. PV is a subtype of myeloproliferative neoplasms (MPN), causing hyperviscosity and thrombotic complications. It’s symptoms include fatigue, headache and pruritus. It’s incidence ranges from 0.02 to 2.8 per 100,000. The JAK-STAT pathway mainly encompasses normal blood cell production and function, but irregularities can lead to disease conditions.